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Pleiotropy of morphogens

  
     

THE LAB

Our research focuses on the molecular mechanisms underlying the multiple roles of morphogens during nervous system development. Our lab is part of the Centre for Neuroscience of Sorbonne University (NeuroSU), which hosts many other research teams devoted the study of the nervous system from its development to neural plasticity, activity and pathology. Our research center is affiliated to the Inserm (French National Institute for Medical Research), the CNRS (National Center for Scientific Research) and the Sorbonne University. .
 

OUR RESEARCH

How do morphogenic signals control distinct responses during neural development?

During embryonic development, the formation of the brain by the generation, differentiation and finally the precise connection of new neurons is controlled by many molecular factors. Amongst these factors, extracellular secreted molecules, called morphogens, instruct the shape of the nervous system. During neuronal differentiation, cells change from a proliferative state to acquire cell identity, to perform migration and finally to grow axons and connect to other cell types. Thus, cells need to change their responses to their environment to achieve the correct behavior. Our research addresses fundamental questions on how a single (and then multiple) morphogenic signal(s) act at different steps of neuronal development to induce these different responses. We use the murine and human developing cerebral cortex as a model.

   Experimental approaches

Overall, our projects aim to determine the molecular and temporal bases for morphogenic response modulations during differentiation during the development of the nervous system.

TEACHING

We are involved in teaching programs such as :

FUNDING

Our research team is supported by several funding sources. We would like to thank:     

PUBLICATIONS


People

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Julien Ferent

Principal investigator
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Sara Douceau 

Postdoctoral fellow 
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Tanya Deutsch

PhD student
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Chloe Borowski

PhD student
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Lola Savare

Technician

Contact us

Ferent Lab
NeuroSU / Site Fer à Moulin
INSERM - Sorbonne University - CNRS
8 rue des fossés Saint Marcel
75005 Paris
France
Send us an email
Tel. +33145876235
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Copyright © 2020 Julien Ferent